Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11306487 | 1.00 | DNM1 (0.74) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL28602625 | 1.00 | DNM1 (0.74) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL718747 | 1.00 | DNM1 (0.74) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11404008 | 1.00 | DNM1 (0.74) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL28351453 | 1.00 | DNM1 (0.74) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11150685 | 0.98 | DNM1 (0.72) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL443763 | 0.98 | DNM1 (0.73) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL4448221 | 0.98 | DNM1 (0.73) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL332578 | 0.98 | DNM1 (0.73) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL15889890 | 0.98 | DNM1 (0.73) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4331447-A | ADDING AN OIL FRACTION AS A BINDER TO AN AQUEOUS SLURRY | SANYO CHEMICAL INDUSTRIES, LTD. (JP) | 1982-05-25 | — | — | US | disclosed |