Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | CASP1 | P29466 | 3/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11276381 | 0.91 | MEN1 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11259140 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11271741 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11269694 | 0.82 | ALPG (0.69) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL11267010 | 0.82 | CTDSP1 (0.55) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL11089921 | 0.80 | PTAFR (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11263830 | 0.80 | MEN1 (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11259134 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL11263329 | 0.76 | ALPG (0.58) | KDM4EALDH1A1HPGDCYP1A2MEN1 | |
| SCHEMBL11090785 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348396-A | Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them | HOFFMANN-LA ROCHE INC. (US) | 1982-09-07 | — | — | US | disclosed |