⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7915872 | 0.77 | TBXAS1 (0.56) | — | |
| Hydrochloric Acid SCHEMBL9171754 | 0.76 | TBXAS1 (0.54) | — | |
| SCHEMBL413786 | 0.74 | TBXAS1 (0.63) | — | |
| SCHEMBL1708961 | 0.73 | — | — | |
| SCHEMBL9031096 | 0.73 | TBXAS1 (0.47) | — | |
| SCHEMBL12350 | 0.72 | — | — | |
| SCHEMBL682646 | 0.71 | — | — | |
| SCHEMBL2697302 | 0.71 | CYP11B1 (0.50) | — | |
| SCHEMBL15095689 | 0.71 | TBXAS1 (0.70) | — | |
| SCHEMBL2143890 | 0.71 | TBXAS1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337251-B1 | MONOCYCLIC OR BICYCLIC CARBOCYCLES AND HETEROCYCLES AS FACTOR XA INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2008-08-20 | — | — | EP | claimed |
| CN-108430503-A | Compositions and methods for activating 'interferon gene stimulator' dependent signaling | 艾杜罗生物科技公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-107530415-A | For activating the composition and method of the conduction of \" interferon gene stimulant \" dependent signals | 艾杜罗生物科技公司 | 2018-01-02 | — | — | CN | disclosed |
| EP-2424843-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| EP-2424843-B1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| US-8598217-B2 | Imidazole derivatives and their use as modulators of cyclin dependent kinases | ASTEX THERAPEUTICS LTD. (GB) | 2013-12-03 | — | — | US | disclosed |
| CN-102803225-A | Imidazole derivatives and their use as modulators of cyclin dependent kinases | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
| US-20120101064-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-04-26 | — | — | US | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |
| US-5234937-A | 3,5-di-tertiary-butyl-4-hydroxphenyl oxazolyl methanones and related compounds as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| US-5234939-A | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| US-5187175-A | 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0519996-A1 | IMIDAZOLES | RHONE-POULENC RORER LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-5086064-A | Inhibitor of 5-lipoxygenase, cycloxygenanse and/or both | WARNER-LAMBERT COMPANY (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0455909-A2 | 5-[1-(Imidazol)methyl]-3,3-disubstituted-2(3H) furanone derivatives | MARION MERRELL DOW INC. (US) | 1991-11-13 | — | — | EP | disclosed |
| EP-0449223-A1 | 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxa-zolyl, and imidazolyl methanones and related compounds as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |
| WO-1991013876-A1 | IMIDAZOLES | RHONE-POULENC RORER LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |
| US-5039691-A | Anticholinergic agents | MARION MERRELL DOW INC. (US) | 1991-08-13 | — | — | US | disclosed |