Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693721 | 0.89 | NR2E1 (0.56) | RB1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL11284150 | 0.88 | RB1 (0.64) | RB1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL11275075 | 0.85 | RB1 (0.60) | RB1MAPT | |
| SCHEMBL29991881 | 0.83 | RB1 (0.58) | RB1KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL29991670 | 0.83 | RB1 (0.58) | RB1KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL29991664 | 0.83 | RB1 (0.58) | RB1KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL5520186 | 0.81 | RB1 (0.67) | RB1KDM4ENR2E1HTR5ANISCH | |
| SCHEMBL11283856 | 0.80 | RB1 (0.70) | RB1KDM4ENR2E1DRD2DRD1 | |
| SCHEMBL11286535 | 0.80 | RB1 (0.69) | RB1KDM4ENR2E1HTR5ANISCH | |
| SCHEMBL4282646 | 0.79 | RB1 (0.53) | RB1KDM4ESIRT1NR2E1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4343812-A | Antidepressant 2-amino-and-2-(substituted amino)-cis-hexahydro-carbazoles, compositions and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-08-10 | — | — | US | disclosed |
| EP-0004342-B1 | CARBAZOLES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND INTERMEDIATES THERETO | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-07-15 | — | — | EP | disclosed |
| US-4254134-A | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles | ENDO LABORATORIES, INC. (US) | 1981-03-03 | — | — | US | disclosed |
| EP-0004342-A1 | Carbazoles, process for their preparation, pharmaceutical compositions containing them, and intermediates thereto | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-10-03 | — | — | EP | disclosed |