Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 11/20 | 0.67 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23875579 | 0.89 | NR2E1 (0.58) | RB1NR2E1HTR2AHTR2C | |
| SCHEMBL11283856 | 0.82 | RB1 (0.70) | RB1NR2E1DRD2DRD1DRD5 | |
| Hydrochloric Acid SCHEMBL11281142 | 0.81 | RB1 (0.68) | RB1NR2E1DRD2DRD1DRD5 | |
| SCHEMBL11276509 | 0.81 | RB1 (0.65) | RB1NR2E1DRD2DRD1DRD5 | |
| SCHEMBL11286535 | 0.79 | RB1 (0.69) | RB1NR2E1DRD2DRD1DRD5 | |
| Hydrochloric Acid SCHEMBL11271931 | 0.78 | RB1 (0.70) | RB1NR2E1DRD2DRD1DRD5 | |
| SCHEMBL8579183 | 0.77 | RB1 (0.63) | RB1NR2E1DRD2DRD1DRD5 | |
| SCHEMBL11284150 | 0.77 | RB1 (0.64) | RB1KDM4E | |
| SCHEMBL4905673 | 0.75 | NR2E1 (0.79) | RB1NR2E1DRD2DRD1DRD5 | |
| SCHEMBL6533665 | 0.75 | NR2E1 (0.79) | RB1NR2E1DRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856126-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006089053-A2 | CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |