Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277489 | 1.00 | HDAC8 (0.41) | HDAC8CHRM5CHKAHTTMAPT | |
| SCHEMBL11335960 | 0.76 | APP (0.39) | HTTMAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL8051285 | 0.73 | — | — | |
| SCHEMBL28057478 | 0.67 | HDAC8 (0.44) | HDAC8HTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL3963260 | 0.65 | HDAC8 (0.42) | HDAC8HTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL3962374 | 0.65 | HDAC8 (0.42) | HDAC8HTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL738655 | 0.64 | — | — | |
| SCHEMBL10854666 | 0.64 | GRM5 (0.42) | HTTMAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL6218827 | 0.64 | MAPT (0.50) | CHRM5CHKAHTTMAPTSMN1; SMN2 | |
| SCHEMBL5033464 | 0.63 | HDAC8 (0.58) | HDAC8CHRM5CHKAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4331672-A | 5-(Pyridinyl)pyridine-2-hydrazines, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1982-05-25 | — | — | US | disclosed |