Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286732 | 0.87 | HTR2C (0.54) | HTR2CHTR2AIGF1RHRH1KDM4E | |
| SCHEMBL11286718 | 0.85 | HTR2A (0.65) | HTR2CHTR2AIGF1RHRH1KDM4E | |
| SCHEMBL11290490 | 0.84 | HTR2C (0.53) | HTR2CHTR2AIGF1RHRH1KDM4E | |
| SCHEMBL11279746 | 0.82 | HTR2A (0.65) | HTR2CHTR2AIGF1RHRH1KDM4E | |
| SCHEMBL11287087 | 0.81 | VCP (0.40) | HTR2CHTR2AIGF1RKDM4EHPGD | |
| SCHEMBL11204214 | 0.77 | KDM4E (0.53) | HTR2CKDM4EHPGDUSP2SMN1; SMN2 | |
| SCHEMBL10512778 | 0.77 | HTR2C (0.68) | HTR2CHTR2AIGF1RHRH1KDM4E | |
| SCHEMBL11392176 | 0.77 | HTR2C (0.72) | HTR2CHTR2AHRH1KDM4EHPGD | |
| SCHEMBL11206910 | 0.76 | KDM4E (0.52) | HTR2CKDM4EHPGDUSP2SMN1; SMN2 | |
| SCHEMBL11284926 | 0.76 | HTR2A (0.67) | HTR2CHTR2AHRH1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0022481-A1 | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions | Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) | 1981-01-21 | — | — | EP | disclosed |