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VCP

Transitional endoplasmic reticulum ATPase · P55072 · VCP on Sugi Atlas →

34,853 patent compounds predicted against VCP, 20,407 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL253841 SCHEMBL253841 0.39 8/20
Cyprazepam Cyprazepam (SCHEMBL114194) 0.39 8/20
SCHEMBL290595 SCHEMBL290595 0.41 7/20
SCHEMBL249562 SCHEMBL249562 0.67 6/20
SCHEMBL250114 SCHEMBL250114 0.65 6/20
SCHEMBL250576 SCHEMBL250576 0.65 6/20
SCHEMBL233939 SCHEMBL233939 0.56 6/20
SCHEMBL233940 SCHEMBL233940 0.56 6/20
SCHEMBL208320 SCHEMBL208320 0.71 5/20
SCHEMBL206333 SCHEMBL206333 0.67 5/20
SCHEMBL248273 SCHEMBL248273 0.51 5/20
SCHEMBL250132 SCHEMBL250132 0.51 5/20
SCHEMBL127767 SCHEMBL127767 0.38 5/20
SCHEMBL206229 SCHEMBL206229 0.76 4/20
SCHEMBL208192 SCHEMBL208192 0.68 4/20
SCHEMBL206148 SCHEMBL206148 0.66 4/20
SCHEMBL207590 SCHEMBL207590 0.64 4/20
SCHEMBL259303 SCHEMBL259303 0.61 4/20
SCHEMBL205889 SCHEMBL205889 0.60 4/20
SCHEMBL180361 SCHEMBL180361 0.53 4/20

Clinical trials — most relevant to VCP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Liraglutide on ER Stress in Obese Patients With Type 2 Diabetes PHASE4UNKNOWN
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy PHASE2COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension PHASE1/PHASE2RECRUITING
Copper Histidine Therapy for Menkes Diseases PHASE1/PHASE2COMPLETED
A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia PHASE2WITHDRAWN
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis PHASE1WITHDRAWN
PBA Use for Treatment of ATF6-/- Patients EARLY_PHASE1SUSPENDED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) EARLY_PHASE1COMPLETED
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction EARLY_PHASE1RECRUITING
Quantification of GADD34 Expression in RA nanCOMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise nanCOMPLETED
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study nanRECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population nanCOMPLETED
Nuclear Myosin VI - a Therapeutic Target in Breast Cancer nanUNKNOWN
A Study to Evaluate and Characterize the Effect of Pharmacological Chemicals on Blood From Patients With Gaucher Disease nanCOMPLETED
Vacuolar ATPase and Drug Resistance of High Grade Gliomas nanUNKNOWN
The Energetic Origin of Neurodegeneration in MS nanCOMPLETED
Autophagy Bladder Cancer nanUNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
Clinical and Genetic Examinations of Dilated Cardiomyopathy nanCOMPLETED
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a VCP binder may also engage these)

ProteinNameSimilarity
P03974 — 1.000 P03974 →
P46462 — 1.000 P46462 →
Q6GL04 — 1.000 Q6GL04 →
Q3ZBT1 — 1.000 Q3ZBT1 →
Q01853 — 1.000 Q01853 →
Q7ZU99 — 1.000 Q7ZU99 →
P23787 — 0.999 P23787 →
Q9LZF6 — 0.998 Q9LZF6 →
P54811 — 0.998 P54811 →
Q9SCN8 — 0.998 Q9SCN8 →
P54609 — 0.997 P54609 →
Q96372 — 0.997 Q96372 →
P54774 — 0.997 P54774 →
P54812 — 0.996 P54812 →
Q5AWS6 — 0.996 Q5AWS6 →
Q7KN62 — 0.995 Q7KN62 →
Q9P3A7 — 0.994 Q9P3A7 →
P25694 — 0.994 P25694 →
P32794 — 0.990 P32794 →
Q8SSJ5 — 0.988 Q8SSJ5 →
P52917 — 0.987 P52917 →
Q0VD48 — 0.987 Q0VD48 →
P46467 — 0.987 P46467 →
Q9ZNT0 — 0.987 Q9ZNT0 →
Q5AG40 — 0.986 Q5AG40 →
P46465 — 0.984 P46465 →
B8D065 — 0.984 B8D065 →
Q9P7J5 — 0.983 Q9P7J5 →
Q8VEJ9 — 0.983 Q8VEJ9 →
Q2KIW6 — 0.983 Q2KIW6 →