Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 14/20 | 0.87 |
| ▸ | ACE2 | Q9BYF1 | 9/20 | 0.87 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280512 | 0.93 | ACE (1.00) | ACEACE2 | |
| SCHEMBL11121801 | 0.90 | ACE (0.70) | ACEACE2KLK5ALDH1A1CYP3A4 | |
| SCHEMBL11121798 | 0.90 | ACE (0.70) | ACEACE2KLK5ALDH1A1CYP3A4 | |
| SCHEMBL11122197 | 0.84 | ACE (0.84) | ACEACE2 | |
| SCHEMBL11122199 | 0.84 | ACE (0.84) | ACEACE2 | |
| SCHEMBL11279585 | 0.83 | ACE (0.81) | ACEACE2 | |
| SCHEMBL11124339 | 0.83 | ACE (0.81) | ACEACE2 | |
| SCHEMBL11124347 | 0.83 | ACE (0.81) | ACEACE2 | |
| SCHEMBL11124578 | 0.82 | ACE (0.66) | ACEACE2KLK5 | |
| SCHEMBL11124576 | 0.82 | ACE (0.66) | ACEACE2KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329473-A | HYPOTENSIVE AGENTS | SRI INTERNATIONAL | 1982-05-11 | — | — | US | claimed |
| US-4329473-A | HYPOTENSIVE AGENTS | SRI INTERNATIONAL | 1982-05-11 | — | — | US | disclosed |