Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10795900 | 0.81 | PDE4A (0.36) | PDE5APDE4ALMNATSHRGRM2 | |
| SCHEMBL10795837 | 0.77 | PDE5A (0.35) | PDE5APDE4ALMNATSHRGRM2 | |
| SCHEMBL10799560 | 0.73 | TSHR (0.34) | PDE5APDE4ALMNATSHRGRM2 | |
| SCHEMBL10796193 | 0.70 | PDE4A (0.38) | PDE4ALMNASMN1; SMN2TSHRMAPT | |
| SCHEMBL11396342 | 0.70 | TSHR (0.55) | PDE4ASMN1; SMN2TSHRALDH1A1POLB | |
| SCHEMBL10795549 | 0.69 | TSHR (0.54) | LMNASMN1; SMN2TSHRPOLBGRM2 | |
| Water SCHEMBL10795625 | 0.69 | TSHR (0.54) | PDE4ASMN1; SMN2TSHRALDH1A1POLB | |
| SCHEMBL11060686 | 0.67 | TSHR (0.51) | PDE5ASMN1; SMN2TSHRMAPTALDH1A1 | |
| SCHEMBL10796025 | 0.67 | TSHR (0.51) | PDE4ASMN1; SMN2TSHRPOLB | |
| SCHEMBL11872380 | 0.65 | TSHR (0.51) | PDE5ASMN1; SMN2TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4366156-A | Antiallergic methods using diazaheterocyclopurines | MEAD JOHNSON & COMPANY (US) | 1982-12-28 | — | — | US | claimed |
| US-4298734-A | PHOSPHODIESTERASE INHIBITORS, BRONCHODILATORS, PERIPHERAL VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1981-11-03 | — | — | US | claimed |