Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 6/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | EED | O75530 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | HLA-A | P04439 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11486753 | 0.92 | SSTR5 (0.73) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL11478926 | 0.85 | HPGD (0.52) | SSTR5LMNAGAAMEN1TP53 | |
| SCHEMBL9681405 | 0.84 | SSTR5 (0.71) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL9698238 | 0.84 | SSTR5 (0.76) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL11472239 | 0.82 | SSTR5 (0.55) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL11271737 | 0.82 | SSTR5 (0.68) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL9698374 | 0.81 | KCNH2 (0.83) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL11381151 | 0.81 | SSTR5 (0.88) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL26350295 | 0.81 | KCNH2 (0.79) | SSTR5KCNH2NR4A2OPRM1OPRD1 | |
| SCHEMBL9697184 | 0.80 | KCNH2 (0.71) | SSTR5KCNH2NR4A2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005318-B1 | N-HETEROCYCLYL-4-PIPERIDINAMINES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, INTERMEDIATES THEREFOR, AND METHOD FOR THE PREPARATION OF THE INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-01-06 | — | — | EP | disclosed |
| US-4219559-A | N-Heterocyclyl-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-08-26 | — | — | US | disclosed |