Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | PDE5A | O76074 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | PTAFR | P25105 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PDE1A | P54750 | 1/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11322854 | 0.79 | PDE3B (0.81) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11324828 | 0.79 | PDE3B (0.81) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11324806 | 0.79 | PDE3B (0.66) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11325432 | 0.79 | PDE3B (0.71) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11276302 | 0.79 | PDE3B (0.56) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11317158 | 0.78 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| Cilostamide SCHEMBL49742 | 0.78 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| Cilostamide SCHEMBL29491047 | 0.78 | PDE3B (1.00) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL6250268 | 0.77 | PDE3B (0.77) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11310341 | 0.76 | PDE3B (0.79) | PDE3BPDE3AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |