Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.42 |
| ▸ | PRNP | P04156 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273567 | 0.86 | KMT2A (0.45) | MAPTHTTNPC1RAB9ATDP1 | |
| SCHEMBL11268673 | 0.83 | KDM4E (0.46) | MAPTHTTNPC1RAB9ATDP1 | |
| SCHEMBL11284124 | 0.79 | PDE3A (0.43) | MAPTHTTNPC1RAB9ATDP1 | |
| SCHEMBL11293586 | 0.78 | PDE3B (0.51) | PDGFRBPDGFRAMEN1KMT2AALDH1A1 | |
| Quinoline SCHEMBL11280764 | 0.77 | MCL1 (0.44) | MAPTHTTNPC1RAB9ATDP1 | |
| SCHEMBL11281239 | 0.77 | PDGFRB (0.41) | PDGFRBPDGFRAMEN1KMT2AALDH1A1 | |
| SCHEMBL11270789 | 0.77 | MAPT (0.43) | MAPTHTTNPC1RAB9ATDP1 | |
| SCHEMBL11270533 | 0.77 | KDM4E (0.44) | PDGFRBPDGFRAMEN1KMT2AALDH1A1 | |
| SCHEMBL11276023 | 0.77 | F11 (0.50) | MAPTHTTMEN1KMT2AALDH1A1 | |
| SCHEMBL11282334 | 0.77 | PDE3B (0.44) | MAPTHTTNPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |