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Sugi Predict / Targets / F11

F11

Coagulation factor XI · P03951 · F11 on Sugi Atlas →

79,152 patent compounds predicted against F11, 47,771 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL392453 SCHEMBL392453 1.00 20/20
SCHEMBL392454 SCHEMBL392454 1.00 20/20
SCHEMBL392905 SCHEMBL392905 1.00 20/20
SCHEMBL393168 SCHEMBL393168 1.00 20/20
SCHEMBL393169 SCHEMBL393169 1.00 20/20
SCHEMBL393592 SCHEMBL393592 1.00 20/20
SCHEMBL393593 SCHEMBL393593 1.00 20/20
SCHEMBL478224 SCHEMBL478224 1.00 20/20
SCHEMBL478225 SCHEMBL478225 1.00 20/20
SCHEMBL478261 SCHEMBL478261 1.00 20/20
SCHEMBL478262 SCHEMBL478262 1.00 20/20
SCHEMBL478263 SCHEMBL478263 1.00 20/20
SCHEMBL478264 SCHEMBL478264 1.00 20/20
SCHEMBL478286 SCHEMBL478286 1.00 20/20
SCHEMBL478287 SCHEMBL478287 1.00 20/20
SCHEMBL393831 SCHEMBL393831 0.92 20/20
SCHEMBL478318 SCHEMBL478318 0.91 20/20
SCHEMBL478319 SCHEMBL478319 0.91 20/20
SCHEMBL478216 SCHEMBL478216 0.89 20/20
SCHEMBL478217 SCHEMBL478217 0.89 20/20

Clinical trials — most relevant to F11 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Assessing Different FVIII Doses and Frequencies in Immune Tolerance Induction (ITI) with ADVATE Among Hemophilia a Boys with Inhibitor (INITIATE Study) PHASE4RECRUITING
Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography PHASE4UNKNOWN
Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor PHASE4RECRUITING
An Open Label Study to Determine the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A. PHASE3COMPLETED
Study of Recombinant Factor IX Product, IB1001, in Previously Treated Subjects With Hemophilia B PHASE3WITHDRAWN
Phase III Expansion Trial for Determining the Safety and Efficacy of Recombinant Human Coagulation Factor VIII-Fc Fusion Protein for Injection in Adolescent and Adult Patients With Hemophilia A PHASE3COMPLETED
Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Chinese Subjects With Hemophilia B Previously Treated With FIX Therapy PHASE3ACTIVE_NOT_RECRUITING
Evaluation of SCT800 in Prophylaxis Therapy on Previous Treated Patients With Severe Hemophilia A PHASE3COMPLETED
Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B PHASE2COMPLETED
CSL Behring Sclero XIII PHASE2UNKNOWN
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome PHASE1COMPLETED
Safety and Dosing Evaluation of REG1 Anticoagulation System PHASE1COMPLETED
Single Ascending Dose of FXI-GalNAc-siRNA in Healthy Subjects PHASE1UNKNOWN
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects nanUNKNOWN
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster. nanRECRUITING
Heparin Management During Cardiopulmonary Bypass in Children nanCOMPLETED
Risk Markers in the Acute Coronary Syndromes nanCOMPLETED
Correlation Between PT and INR to Factor 7 nanUNKNOWN
Cross-sectional Study on Prevalence of Coagulation Factors Deficiency in Assiut University Children Hospital nanUNKNOWN
Effect of Bevacizumab and VEGF on Platelet Clustering in Patients Who Are Receiving Bevacizumab for Cancer nanUNKNOWN
Recombinant Activated Factor VII in the Management of Massive Bleeding in Hospital Universiti Sains Malaysia nanCOMPLETED
Factor XI Levels in Acute Ischemic Stroke nanCOMPLETED
Intra-graft Coagulation Events in Clinical Renal Transplantation and Delayed Graft Function nanUNKNOWN
Mechanism and Repository Study for the Red Cell Storage Duration Study nanCOMPLETED
Rare Bleeding Disorders in the Netherlands nanUNKNOWN
Factor XIII Activity in Gastrointestinal Bleedings nanCOMPLETED
Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A nanUNKNOWN
Belgian Antithrombin Deficiency Registry nanNOT_YET_RECRUITING
Hemostasis in Sickle Cell Disease--Infancy to Adulthood nanCOMPLETED
Patterns of Hemophilia Care in Assiut Children Patients nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a F11 binder may also engage these)

ProteinNameSimilarity
Q2KJ63 — 1.000 Q2KJ63 →
P26262 — 1.000 P26262 →
Q91Y47 — 1.000 Q91Y47 →
Q5NTB3 — 1.000 Q5NTB3 →
P14272 — 1.000 P14272 →
KLKB1 Plasma kallikrein 1.000 landscape →
HGF Hepatocyte growth factor 0.992 landscape →
P17945 — 0.991 P17945 →
Q58L93 — 0.991 Q58L93 →
P19637 — 0.990 P19637 →
Q6ZWK6 — 0.990 Q6ZWK6 →
Q66TN7 — 0.990 Q66TN7 →
P11214 — 0.990 P11214 →
P29598 — 0.990 P29598 →
P49150 — 0.990 P49150 →
Q90WD8 — 0.990 Q90WD8 →
Q7RTY8 — 0.989 Q7RTY8 →
Q8BIK6 — 0.989 Q8BIK6 →
Q08048 — 0.989 Q08048 →
P33587 — 0.989 P33587 →
P04185 — 0.989 P04185 →
TMPRSS4 Transmembrane protease serine 4 0.989 landscape →
P31394 — 0.989 P31394 →
P79953 — 0.989 P79953 →
Q1L659 — 0.989 Q1L659 →
Q5R8J0 — 0.988 Q5R8J0 →
Q58L94 — 0.988 Q58L94 →
P18292 — 0.988 P18292 →
P83370 — 0.988 P83370 →
Q1L658 — 0.988 Q1L658 →