⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1187152 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4597249 | 0.97 | ACHE (0.40) | — | |
| SCHEMBL11738424 | 0.86 | — | — | |
| SCHEMBL8747536 | 0.86 | — | — | |
| SCHEMBL18175753 | 0.86 | — | — | |
| SCHEMBL18686942 | 0.86 | — | — | |
| SCHEMBL14084426 | 0.72 | — | — | |
| SCHEMBL29752582 | 0.72 | ACHE (0.46) | — | |
| SCHEMBL13014856 | 0.69 | — | — | |
| SCHEMBL1776811 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641598-B | Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates | CELL THERAPEUTICS EUROPE SRL | 2014-09-24 | — | — | CN | claimed |
| US-8318503-B2 | Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates | CELL THERAPEUTICS, INC. (US) | 2012-11-27 | — | — | US | claimed |
| EP-2282997-A2 | 4-METHYL-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE USEFUL AS CANNABINOID CB1 NEUTRAL ANTAGONIST | Laboratorios del Dr. Esteve S.A. (ES) | 2011-02-16 | — | — | EP | claimed |
| US-20110028517-A1 | 4-METHYL-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE USEFUL AS A CANNABINOID CB1 NEUTRAL ANTAGONIST | LABORATORIOS DEL DR. ESTEVE, S.A. | 2011-02-03 | — | — | US | claimed |
| EP-1967854-B1 | Method for determining the amount of conjugated taxane in polyglutamic acid-taxane conjugates | CELL THERAPEUTICS EUROPE SRL (IT) | 2010-11-03 | — | — | EP | claimed |
| US-20100151582-A1 | METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUT ACID-TAXANE CONJUGATES | CELL THERAPEUTICS, INC. (US) | 2010-06-17 | — | — | US | claimed |
| WO-2009124950-A2 | 4-METHYL-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE USEFUL AS A CANNABINOID CB1 NEUTRAL ANTAGONIST | LABORATORIOS DEL DR. ESTEVE, S. A. (ES) | 2009-10-15 | — | — | WO | claimed |
| EP-2108643-A1 | 4-methyl-4, 5-dihydro-1H-pyrazole-3-carboxamide useful as a cannabinoid CB1 neutral antagonist | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-10-14 | — | — | EP | claimed |
| WO-2008107174-A1 | METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUT ACID-TAXANE CONJUGATES | CELL THERAPEUTICS INC. (US) | 2008-09-12 | — | — | WO | claimed |
| EP-1967854-A1 | Method for determining the amount of conjugated taxane in polyglutamic acid-taxane conjugates | Cell Therapeutics Europe S.R.L. (IT) | 2008-09-10 | — | — | EP | claimed |
| CN-101641598-B | Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates | CELL THERAPEUTICS EUROPE SRL | 2014-09-24 | — | — | CN | disclosed |
| US-8318503-B2 | Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates | CELL THERAPEUTICS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20110159086-A1 | PHARMACEUTICAL FORMULATION COMPRISING A CB1-RECEPTOR COMPOUND IN A SOLID SOLUTION AND/OR SOLID DISPERSION | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-06-30 | — | — | US | disclosed |
| EP-2314578-A1 | Cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid, useful as intermediate in the preparation of cannabinoid CB1 neutral antagonists | Esteve Química, S.A. (ES) | 2011-04-27 | — | — | EP | disclosed |
| EP-2282997-A2 | 4-METHYL-4,5-DIHYDRO-1H-PYRAZOLE-3-CARBOXAMIDE USEFUL AS CANNABINOID CB1 NEUTRAL ANTAGONIST | Laboratorios del Dr. Esteve S.A. (ES) | 2011-02-16 | — | — | EP | disclosed |
| EP-0655450-A1 | Process for the production of sydnonimium hydrogensulphate and novel intermediates | CASSELLA Aktiengesellschaft (DE) | 1995-05-31 | — | — | EP | disclosed |
| EP-0613474-A1 | METHOD OF PREPARING 1-AMINO-2,6-DIMETHYLPIPERIDINE | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-07 | — | — | EP | disclosed |
| EP-0613473-A1 | METHOD OF PREPARING 1-AMINO-2,6-DIMETHYLPIPERIDINE | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993010110-A1 | METHOD OF PREPARING 1-AMINO-2,6-DIMETHYLPIPERIDINE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1993-05-27 | — | — | WO | disclosed |
| WO-1993010109-A1 | METHOD OF PREPARING 1-AMINO-2,6-DIMETHYLPIPERIDINE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1993-05-27 | — | — | WO | disclosed |