Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | CTSE | P14091 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128367 | 0.89 | CYP3A4 (0.57) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL2020756 | 0.88 | CYP3A4 (0.79) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128343 | 0.87 | CYP3A4 (0.81) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128290 | 0.86 | CYP3A4 (0.79) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL2016500 | 0.86 | CYP3A4 (0.79) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128336 | 0.86 | CYP3A4 (0.79) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128622 | 0.85 | CYP3A4 (0.78) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128233 | 0.85 | CYP3A4 (0.78) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL1128574 | 0.85 | CYP3A4 (0.77) | CYP3A4CYP2C9NR3C1GPR119PIK3CA | |
| SCHEMBL2018829 | 0.85 | CYP3A4 (0.75) | CYP3A4CYP2C9NR3C1GPR119PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283019-A1 | GPR119 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | claimed |
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | claimed |
| EP-2283019-A1 | GPR119 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | disclosed |