Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128310 | 0.89 | CYP3A4 (0.72) | CYP3A4GPR119CYP2C9PIK3CAMTOR | |
| SCHEMBL2019853 | 0.86 | CYP3A4 (0.61) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL1128724 | 0.86 | CYP3A4 (0.61) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL1128407 | 0.84 | CYP3A4 (0.79) | CYP3A4GPR119CYP2C9KCNH2 | |
| SCHEMBL1128465 | 0.84 | CYP3A4 (0.59) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL2016396 | 0.83 | CYP3A4 (0.57) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL2017035 | 0.81 | CYP3A4 (0.55) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL4357368 | 0.80 | CYP3A4 (0.54) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL2021684 | 0.80 | CYP3A4 (0.54) | CYP3A4GPR119CYP2C9KCNH2PIK3CA | |
| SCHEMBL2016691 | 0.80 | CYP3A4 (0.54) | CYP3A4GPR119CYP2C9KCNH2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283019-A1 | GPR119 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | claimed |
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | claimed |
| EP-2283019-A1 | GPR119 RECEPTOR AGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141238-A1 | GPR119 RECEPTOR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-26 | — | — | WO | disclosed |