Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL405151 | 1.00 | KDM6B (0.44) | KDM6BKDM5CEGLN1PHF8KDM2A | |
| SCHEMBL156391 | 0.94 | — | — | |
| SCHEMBL10764532 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL7488654 | 0.90 | — | — | |
| SCHEMBL743846 | 0.90 | — | — | |
| SCHEMBL8995960 | 0.73 | ALDH1A1 (0.41) | KDM6BKDM5CEGLN1PHF8KDM2A | |
| SCHEMBL10619133 | 0.73 | — | — | |
| Acetic Acid SCHEMBL9621249 | 0.71 | FFAR3 (0.70) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL153379 | 0.71 | — | — | |
| SCHEMBL28818985 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642766-B2 | Synthesis of (+) cortistatin A and related compounds | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-02-04 | — | — | US | disclosed |
| EP-2283159-B1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2013-10-09 | — | — | EP | disclosed |
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-03-10 | — | — | US | disclosed |
| EP-2283159-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | The Scripps Research Institute (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137335-A1 | SYNTHESIS OF (+) CORSTISTATIN A AND RELATED COMPOUNDS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | CTTN, CIAPIN1, PACSIN2 | KDM6B 4019/4885KDM5C 4014/4885EGLN1 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.