SCHEMBL11283545

SCHEMBL11283545

COC(=O)[C@@H](N)Cc1c[nH]c2cc(Cl)ccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.53
NR4A2 P43354 1/20 0.53
SOS1 Q07889 6/20 0.52
GPR84 Q9NQS5 1/20 0.51
MAPT P10636 2/20 0.51
TP53 P04637 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TACR1 P25103 2/20 0.50
ADRB3 P13945 1/20 0.48
PTPRA P18433 1/20 0.48
HDAC8 Q9BY41 1/20 0.47
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
LMNA P02545 1/20 0.47
MPO P05164 1/20 0.47
TSHR P16473 1/20 0.47
BLM P54132 1/20 0.47
PMP22 Q01453 1/20 0.47
KMT2A Q03164 1/20 0.47
HIF1A Q16665 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11283543 1.00 HTR2A (0.53) HTR2ANR4A2SOS1GPR84MAPT
Hydrochloric Acid SCHEMBL28173823 0.99 HTR2A (0.52) HTR2ANR4A2SOS1GPR84MAPT
SCHEMBL19489919 0.90 HTR2A (0.64) HTR2ANR4A2SOS1GPR84MAPT
Hydrochloric Acid SCHEMBL28174729 0.89 HTR2A (0.62) HTR2ANR4A2SOS1MAPTTP53
SCHEMBL15313351 0.89 SOS1 (0.53) HTR2ANR4A2SOS1GPR84MAPT
SCHEMBL18427690 0.88 HTR2A (0.51) HTR2ANR4A2SOS1GPR84MAPT
SCHEMBL24113523 0.86 TACR1 (0.57) HTR2ANR4A2SOS1MAPTTACR1
SCHEMBL1196763 0.86 TACR1 (0.57) HTR2ANR4A2SOS1MAPTTACR1
SCHEMBL20931090 0.86 TACR1 (0.54) HTR2ASOS1MAPTTACR1PTPRA
SCHEMBL30310544 0.86 TACR1 (0.57) HTR2ANR4A2SOS1MAPTTACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705304-A1 AMIDO PYRIDO[3,4-B]INDOLE-1, 4-DIONE COMPOUNDS FOR TREATMENT OF PORPHYRIAS Portal Therapeutics, Inc. (US) 2026-03-11 EP disclosed
WO-2024226881-A1 AMIDO PYRIDO[3,4-B]INDOLE-1, 4-DIONE COMPOUNDS FOR TREATMENT OF PORPHYRIAS PORTAL THERAPEUTICS, INC. (US) 2024-10-31 WO disclosed
US-4316847-A ARTIFICIAL SWEETENING HOFFMANN-LA ROCHE INC. (US) 1982-02-23 US disclosed
US-4256641-A ALKYL ALPHA-CARBOXAMIDOINDOLE-3-ACRYLATES MADE FROM 3-INDOLECARBOXALDEHYDES AND MONOALKYL CARBOXAMIDOMALONATES HOFFMANN-LA ROCHE INC. (US) 1981-03-17 US disclosed
US-4140697-A ARTIFICIAL SWEETENER HOFFMANN-LA ROCHE INC. (US) 1979-02-20 US disclosed
US-4073795-A Synthesis of tryptophans HOFFMANN-LA ROCHE INC. (US) 1978-02-14 US disclosed