Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 7/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
| ▸ | PTPRA | P18433 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18427690 | 0.89 | HTR2A (0.51) | SOS1GPR84HTR2ATACR1PTPRA | |
| SCHEMBL11283545 | 0.89 | HTR2A (0.53) | SOS1GPR84HTR2ATACR1PTPRA | |
| SCHEMBL11283543 | 0.89 | HTR2A (0.53) | SOS1GPR84HTR2ATACR1PTPRA | |
| Hydrochloric Acid SCHEMBL28173823 | 0.88 | HTR2A (0.52) | SOS1GPR84HTR2ATACR1PTPRA | |
| SCHEMBL18029175 | 0.85 | KMT2A (0.66) | SOS1GPR84HTR2APTPRAKDM4E | |
| SCHEMBL30381542 | 0.85 | KMT2A (0.66) | SOS1GPR84HTR2APTPRAKDM4E | |
| SCHEMBL456668 | 0.85 | KMT2A (0.66) | SOS1GPR84HTR2APTPRAKDM4E | |
| SCHEMBL29405769 | 0.85 | KMT2A (0.66) | SOS1GPR84HTR2APTPRAKDM4E | |
| SCHEMBL10958198 | 0.85 | SCN9A (0.59) | SOS1GPR84HTR2APTPRAKDM4E | |
| SCHEMBL623336 | 0.85 | KMT2A (0.66) | SOS1GPR84HTR2APTPRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10471120-B2 | Peptidomimetic macrocycles and uses thereof | AILERON THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-9505804-B2 | Peptidomimetic macrocycles | AILERON THERAPEUTICS, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160193283-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | AILERON THERAPEUTICS, INC. | 2016-07-07 | — | — | US | disclosed |
| US-20150051155-A1 | PEPTIDOMIMETIC MACROCYCLES | HOFFMANN-LA ROCHE, INC. | 2015-02-19 | — | — | US | disclosed |
| US-20130274205-A1 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193283-A1 | PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF | TP53, TP53BP1, MDM2 | SOS1 1922/4885GPR84 2358/4885HTR2A 4410/4885 |
| US-20150051155-A1 | PEPTIDOMIMETIC MACROCYCLES | TP53, MDM2, MDM4 | SOS1 1976/4885GPR84 2792/4885HTR2A 3792/4885 |
| US-10471120-B2 | Peptidomimetic macrocycles and uses thereof | TP53, TP53BP1, MDM2 | SOS1 1922/4885GPR84 2358/4885HTR2A 4410/4885 |
| US-20130274205-A1 | PEPTIDOMIMETIC MACROCYCLES | PROKR1, GLP1R, PROKR2 | SOS1 3238/4885GPR84 763/4885HTR2A 3724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.