SCHEMBL11285481

SCHEMBL11285481

Nc1cc(Cl)ccc1C1=NCCN1

nearest known ligand 0.71

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 6/20 0.54
LMNA P02545 1/20 0.53
RECQL P46063 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11301090 0.87 LMNA (0.53) NISCHLMNARECQL
SCHEMBL22743021 0.80 NISCH (0.46) NISCH
SCHEMBL11517310 0.80 NISCH (0.60) NISCHLMNARECQL
SCHEMBL31552847 0.80 NISCH (0.46) NISCH
SCHEMBL11517317 0.77 NISCH (0.67) NISCHLMNARECQL
SCHEMBL18824619 0.77 LMNA (0.53) NISCHLMNARECQL
SCHEMBL31743071 0.76 NISCH (0.54) NISCHLMNARECQL
SCHEMBL2258437 0.76 NISCH (0.58) NISCH
SCHEMBL8239326 0.76 NISCH (0.57) NISCHLMNARECQL
SCHEMBL80782 0.75 NISCH (0.62) NISCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0046446-A1 Polyazaheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them CIBA-GEIGY AG (CH) 1982-02-24 EP disclosed