Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11285199 | 1.00 | PTGS1 (0.53) | PTGS1POLBSRCBRAFKDR | |
| SCHEMBL11362879 | 0.86 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2PKMPTGS2MAPT | |
| SCHEMBL11311508 | 0.86 | MAPT (0.46) | PTGS1POLBSMN1; SMN2PKMPTGS2 | |
| SCHEMBL11286056 | 0.86 | MAPT (0.46) | PTGS1POLBSMN1; SMN2PKMPTGS2 | |
| SCHEMBL11307972 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2PKMMAPTKMT2AMEN1 | |
| SCHEMBL11304536 | 0.86 | SMN1; SMN2 (0.55) | POLBSMN1; SMN2PKMPTGS2MAPT | |
| SCHEMBL11293397 | 0.78 | MAPT (0.47) | POLBSMN1; SMN2PKMMAPTKMT2A | |
| SCHEMBL11306787 | 0.78 | LMNA (0.43) | SRCBRAFKDRSMN1; SMN2PTGS2 | |
| SCHEMBL11283541 | 0.78 | LMNA (0.43) | SRCBRAFKDRSMN1; SMN2PTGS2 | |
| SCHEMBL11252379 | 0.76 | FLT3 (0.50) | SRCBRAFKDRSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051084-A1 | Substituted 1H-1,2,4-triazoles | AMERICAN CYANAMID COMPANY (US) | 1982-05-12 | — | — | EP | disclosed |
| US-4259504-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-03-31 | — | — | US | disclosed |