Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR1A | P08908 | 8/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11295861 | 0.84 | HTR1D (0.50) | HTR1A | |
| SCHEMBL11021273 | 0.83 | HTR2A (0.56) | HTR2AHTR1AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL11280259 | 0.82 | HTR2A (0.55) | HTR2AHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11281420 | 0.82 | HTR2A (0.43) | HTR2A | |
| SCHEMBL11367195 | 0.80 | HTR2A (0.53) | HTR2AHTR1AADRA2ADRD2 | |
| SCHEMBL11288305 | 0.80 | SIGMAR1 (0.53) | ADRA2ADRD2 | |
| Hydrochloric Acid SCHEMBL11367589 | 0.79 | HTR2A (0.53) | HTR2AHTR1AADRA2ADRD2 | |
| SCHEMBL24723815 | 0.77 | HTR2A (0.97) | HTR2AHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL25249411 | 0.77 | HTR2A (1.00) | HTR2AHTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL29633130 | 0.77 | HTR2A (0.97) | HTR2AHTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061333-A1 | 9-(2-(3-Indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones | SYNTEX (U.S.A.) INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4332804-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, ARRHYTHMIA, MIGRAINE, VASOSPASTIC DISORDERS AND ASTHMA | SYNTEX (U.S.A.) INC. (US) | 1982-06-01 | — | — | US | disclosed |