SCHEMBL11286265

SCHEMBL11286265

Clc1ccc(CCC(Cc2ccccc2Cl)Cn2ccnc2)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 6/20 0.50
IDO1 P14902 6/20 0.50
CYP3A4 P08684 5/20 0.50
LMNA P02545 4/20 0.50
NR1I2 O75469 3/20 0.50
NR3C1 P04150 3/20 0.50
CYP1A2 P05177 3/20 0.50
PGR P06401 3/20 0.50
ADORA3 P0DMS8 3/20 0.50
CYP2D6 P10635 3/20 0.50
CYP2C19 P33261 3/20 0.50
OPRK1 P41145 3/20 0.50
SLC6A3 Q01959 3/20 0.50
KCNH2 Q12809 3/20 0.50
CYP19A1 P11511 2/20 0.50
ADRA2B P18089 2/20 0.50
CHRM3 P20309 2/20 0.50
CYP17A1 P05093 2/20 0.50
ADRB1 P08588 2/20 0.50
DRD2 P14416 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11283227 0.94 CYP2C9 (0.53) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11281976 0.90 IDO1 (0.57) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11272390 0.89 IDO1 (0.53) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11269197 0.89 CYP2C9 (0.54) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11274283 0.88 IDO1 (0.54) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11275963 0.87 CYP1A2 (0.60) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11285364 0.86 CYP2C9 (0.52) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11271894 0.86 IDO1 (0.59) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11272865 0.85 CYP2C9 (0.55) CYP2C9IDO1CYP3A4LMNANR1I2
SCHEMBL11272907 0.85 CYP1A2 (0.51) CYP2C9IDO1CYP3A4LMNANR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0064244-A1 Spermicidal 1-bis(arylalkyl)alkylimidazoles SYNTEX (U.S.A.) INC. (US) 1982-11-10 EP disclosed