SCHEMBL11286635

SCHEMBL11286635

Cc1ccc(CC(Cc2ccccc2Cl)Cn2ccnc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.52
CYP11B1 P15538 3/20 0.51
CYP11B2 P19099 3/20 0.51
IDO1 P14902 3/20 0.47
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2D6 P10635 2/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
CYP2C9 P11712 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
HIF1A Q16665 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
NR1I2 O75469 1/20 0.44
ESR1 P03372 1/20 0.44
NR3C1 P04150 1/20 0.44
PGR P06401 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11283823 0.91 ALDH1A1 (0.50) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11278286 0.90 CYP1A2 (0.54) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11276826 0.90 CYP19A1 (0.53) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11285904 0.89 CYP19A1 (0.49) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11281284 0.88 CYP19A1 (0.51) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11276108 0.87 IDO1 (0.50) CYP19A1IDO1CYP1A2CYP3A4ALDH1A1
SCHEMBL11280320 0.86 CYP19A1 (0.56) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11286312 0.85 ALDH1A1 (0.51) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11848160 0.82 CYP19A1 (0.46) CYP19A1CYP11B1CYP11B2IDO1CYP1A2
SCHEMBL11275963 0.81 CYP1A2 (0.60) CYP19A1CYP11B1CYP11B2IDO1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0064244-A1 Spermicidal 1-bis(arylalkyl)alkylimidazoles SYNTEX (U.S.A.) INC. (US) 1982-11-10 EP disclosed