Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
| ▸ | GCG | P01275 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30851304 | 0.84 | CYP2C19 (0.47) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 | |
| SCHEMBL1114199 | 0.84 | CYP2C19 (0.47) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 | |
| SCHEMBL4588820 | 0.84 | DPP4 (0.56) | FFAR4FFAR1DPP4HTR7TDP1 | |
| SCHEMBL3746992 | 0.82 | CYP2C19 (0.50) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 | |
| SCHEMBL1611069 | 0.81 | CYP2C19 (0.45) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 | |
| SCHEMBL16629574 | 0.81 | PPARA (0.46) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 | |
| Methylamine SCHEMBL28217585 | 0.78 | DPP4 (0.55) | DPP4HTR7TDP1ALDH1A1HSD17B10 | |
| SCHEMBL31464099 | 0.78 | FFAR1 (0.46) | FFAR4FFAR1CYP1A2DPP4PTGDR2 | |
| SCHEMBL759109 | 0.78 | FFAR1 (0.46) | FFAR4FFAR1CYP1A2DPP4PTGDR2 | |
| SCHEMBL11994144 | 0.78 | PPARA (0.44) | CYP2C19FFAR4FFAR1CYP1A2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535280-B | Arylsulfonamide compounds | GENENTECH INC | 2012-06-27 | — | — | CN | disclosed |
| CN-102105449-A | Arylsulfonamide compounds, compositions and methods of use | GENENTECH INC | 2011-06-22 | — | — | CN | disclosed |
| CN-101535280-A | Arylsulfonamide compounds | GENENTECH INC (US) | 2009-09-16 | — | — | CN | disclosed |
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |