Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GCG | P01275 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497158 | 0.83 | CYP2C19 (0.53) | CYP2C19FFAR4FFAR1CYP1A2SLC6A4 | |
| SCHEMBL429540 | 0.83 | DPP4 (0.58) | FFAR4FFAR1ALDH1A1DPP4HTR7 | |
| SCHEMBL27840283 | 0.83 | DPP4 (0.58) | FFAR4FFAR1ALDH1A1DPP4HTR7 | |
| SCHEMBL16629574 | 0.82 | PPARA (0.46) | CYP2C19FFAR4FFAR1CYP1A2SLC6A4 | |
| SCHEMBL11287161 | 0.82 | CYP2C19 (0.45) | CYP2C19FFAR4FFAR1ALDH1A1CYP1A2 | |
| SCHEMBL1611069 | 0.82 | CYP2C19 (0.45) | CYP2C19FFAR4FFAR1ALDH1A1CYP1A2 | |
| SCHEMBL7559810 | 0.82 | ALDH1A1 (0.40) | CYP2C19FFAR4FFAR1ALDH1A1NPSR1 | |
| SCHEMBL28332553 | 0.82 | TDP1 (0.54) | FFAR4FFAR1DPP4PTGER1PTGER4 | |
| SCHEMBL29584523 | 0.82 | TDP1 (0.54) | FFAR4FFAR1DPP4PTGER1PTGER4 | |
| SCHEMBL2865404 | 0.82 | ABL1 (0.50) | DPP4KMT2APTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817031-B1 | CASPASE-10 INHIBITORS FOR PREVENTION AND TREATMENT OF RETINOPATHY | MERCK PATENT GMBH (DE) | 2014-05-21 | — | — | EP | claimed |
| EP-1817031-B1 | CASPASE-10 INHIBITORS FOR PREVENTION AND TREATMENT OF RETINOPATHY | MERCK PATENT GMBH (DE) | 2014-05-21 | — | — | EP | disclosed |
| US-7829721-B2 | Specific caspase-10 inhibitors | MERCK PATENT GMBH (DE) | 2010-11-09 | — | — | US | disclosed |
| US-20080255173-A1 | Novel Specific Caspase-10 Inhibitors | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-16 | — | — | US | disclosed |
| EP-1817031-A1 | NOVEL SPECIFIC CASPASE-10 INHIBITORS | Merck Patent GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006058592-A1 | NOVEL SPECIFIC CASPASE-10 INHIBITORS | MERCK PATENT GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255173-A1 | Novel Specific Caspase-10 Inhibitors | CASP10, CASP1, CASP5 | CYP2C19 2904/4885FFAR4 860/4885FFAR1 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.