Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | CES2 | O00748 | 10/20 | 0.50 |
| ▸ | CES1 | P23141 | 9/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698788 | 0.82 | CES2 (0.55) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL10340028 | 0.82 | CES2 (0.52) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL28056567 | 0.81 | CES2 (0.54) | MAPTLMNAALDH1A1NPSR1HTT | |
| SCHEMBL11036513 | 0.79 | MAPT (0.51) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL11108347 | 0.79 | AKT1 (0.40) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL8078446 | 0.78 | AKT1 (0.50) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL9189618 | 0.77 | MAPT (0.62) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL367640 | 0.77 | AKT1 (0.58) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL11847282 | 0.77 | EGFR (0.60) | MAPTLMNAALDH1A1NPSR1USP2 | |
| SCHEMBL4420865 | 0.77 | KDM4E (0.56) | MAPTLMNAALDH1A1NPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013424-B1 | SPIRO(DIBENZO(B,F)THIEPINE-PIPERIDINES), INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-11-17 | — | — | EP | claimed |
| US-4198420-A | Spiro[dibenz(b,f)thiepin-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-04-15 | — | — | US | disclosed |