SCHEMBL11287397

SCHEMBL11287397

c1ccc(C(=C(c2ccccc2)c2conn2)c2conn2)cc1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.31
NPC1 O15118 2/20 0.31
RAB9A P51151 2/20 0.31
CES2 O00748 2/20 0.31
CES1 P23141 2/20 0.31
ALDH1A1 P00352 2/20 0.31
DAO P14920 1/20 0.31
TSHR P16473 1/20 0.31
NAPRT Q6XQN6 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 2/20 0.31
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
PKM P14618 1/20 0.30
HPGD P15428 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27673306 0.77 HPGD (0.41) ALDH1A1KMT2AMAPTHPGDSMN1; SMN2
SCHEMBL38652360 0.67 KMT2A (0.34) ESR1NPC1RAB9ACES2CES1
SCHEMBL1231009 0.66
SCHEMBL27563605 0.66
SCHEMBL67982 0.65 CES1 (0.53) ESR1CES2CES1ALDH1A1DAO
Benzene SCHEMBL28326432 0.65 CES1 (0.53) ESR1CES2CES1ALDH1A1DAO
SCHEMBL4289444 0.64 KMT2A (0.44) ESR1ALDH1A1TSHRKMT2AMEN1
SCHEMBL3230225 0.62 F2 (0.32) ESR1NPC1RAB9ACES2CES1
SCHEMBL1058399 0.62
SCHEMBL1058397 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0006171-B1 STILBENE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS OPTICAL BRIGHTENERS HOECHST AKTIENGESELLSCHAFT (DE) 1982-07-28 EP disclosed