SCHEMBL11288007

SCHEMBL11288007

Clc1ccc(CCC(CCc2ccc(Cl)cc2)CCn2ccnc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.59
CYP2A6 P11509 1/20 0.59
CYP11B1 P15538 1/20 0.59
CYP11B2 P19099 1/20 0.59
CYP2B6 P20813 1/20 0.59
TP53 P04637 2/20 0.54
TSHR P16473 2/20 0.54
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
ALOX15 P16050 1/20 0.54
CYP2C19 P33261 1/20 0.54
HIF1A Q16665 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
NR1I2 O75469 1/20 0.54
ESR1 P03372 1/20 0.54
NR3C1 P04150 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11280325 0.95 CYP19A1 (0.54) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11275221 0.95 CYP19A1 (0.54) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11286228 0.93 CYP19A1 (0.55) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11271821 0.90 CYP1A2 (0.49) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11272761 0.90 ALDH1A1 (0.55) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11274514 0.88 CYP19A1 (0.50) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11307274 0.88 CYP19A1 (0.50) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11275363 0.87 ALDH1A1 (0.62) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11281270 0.86 ALDH1A1 (0.54) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6
SCHEMBL11633191 0.86 CYP2A6 (0.56) CYP19A1CYP2A6CYP11B1CYP11B2CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0064244-A1 Spermicidal 1-bis(arylalkyl)alkylimidazoles SYNTEX (U.S.A.) INC. (US) 1982-11-10 EP disclosed