Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129314 | 0.99 | LMNA (0.53) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL17896066 | 0.91 | LMNA (0.44) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL17895869 | 0.91 | LMNA (0.44) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL17895870 | 0.91 | LMNA (0.44) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL2459551 | 0.88 | LMNA (0.63) | LMNAKDM4EDRD2RECQLHPGD | |
| SCHEMBL2462459 | 0.82 | LMNA (0.46) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL2462310 | 0.82 | LMNA (0.46) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL2462033 | 0.81 | LMNA (0.46) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL13772442 | 0.80 | POLB (0.45) | LMNAKDM4EHTTMEN1KMT2A | |
| SCHEMBL13772610 | 0.80 | POLB (0.45) | LMNAKDM4EHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |