Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778735 | 0.88 | ALOX12 (0.59) | ALOX12POLBDRD2KCNH2DRD4 | |
| SCHEMBL11283550 | 0.85 | NOTUM (0.52) | ALOX12POLBKDM4EMEN1MAPT | |
| SCHEMBL11288016 | 0.84 | NOTUM (0.50) | ALOX12POLBKDM4EMEN1KMT2A | |
| SCHEMBL29562204 | 0.84 | ALOX12 (0.52) | ALOX12POLBDRD2KCNH2DRD4 | |
| SCHEMBL9277091 | 0.83 | ALOX12 (0.51) | ALOX12POLBTDP1DRD2KCNH2 | |
| SCHEMBL29561934 | 0.81 | ALOX12 (0.52) | ALOX12POLBDRD2KCNH2DRD4 | |
| SCHEMBL31402597 | 0.81 | ALOX12 (0.56) | ALOX12POLBDRD2KCNH2DRD4 | |
| SCHEMBL4610933 | 0.81 | ALOX12 (0.56) | ALOX12POLBDRD2KCNH2DRD4 | |
| SCHEMBL11502429 | 0.81 | POLB (0.48) | ALOX12POLBKDM4EMEN1MAPT | |
| SCHEMBL11281275 | 0.81 | ALOX12 (0.47) | ALOX12POLBMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |