ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12 · P18054 · ALOX12 on Sugi Atlas →

384,493 patent compounds predicted against ALOX12, 263,286 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Masoprocol (SCHEMBL3818)	1.00	7/20
SCHEMBL3160	0.90	7/20
SCHEMBL2390	0.85	6/20
Fenticlor (SCHEMBL23276)	0.56	5/20
Melevodopa (SCHEMBL34004)	0.51	5/20
Oxyquinoline (SCHEMBL37189)	0.81	4/20
Oxyquinoline (SCHEMBL25916)	0.78	4/20
Oxyquinoline (SCHEMBL29247)	0.78	4/20
Oxyquinoline (SCHEMBL29248)	0.78	4/20
Flavonol (SCHEMBL20246)	0.77	4/20
SCHEMBL18224	0.50	4/20
SCHEMBL25900	0.47	4/20
Clioquinol (SCHEMBL3967)	1.00	3/20
SCHEMBL15371	1.00	3/20
Thiram (SCHEMBL21144)	1.00	3/20
Diphenylamine (SCHEMBL229)	0.92	3/20
Bis(Dimethylaminethiocarbonyl)Monosulfide (SCHEMBL23048)	0.62	3/20
SCHEMBL31965	0.55	3/20
SCHEMBL31993	0.55	3/20
Carvacrol (SCHEMBL24734)	0.54	3/20

Clinical trials — most relevant to ALOX12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Predicting Response to Standardized Pediatric Colitis Therapy	PHASE4	COMPLETED
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes	PHASE4	UNKNOWN
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients	PHASE4	COMPLETED
The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis	PHASE4	COMPLETED
Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids	PHASE2/PHASE3	COMPLETED
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA	PHASE2/PHASE3	COMPLETED
Aspirin for Uncontrolled Asthma	PHASE3	COMPLETED
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)	PHASE2	COMPLETED
Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model	PHASE2	UNKNOWN
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide	PHASE1	COMPLETED
Electrophilic Fatty Acid Derivatives in Asthma	PHASE1	COMPLETED
Role of 12-lipoxygenase in Platelet Reactivity and Type 2 Diabetes Mellitus	EARLY_PHASE1	COMPLETED
Fatty Acid Regulation of Platelet Function in Diabetes	nan	COMPLETED
Heart & Health Study	nan	COMPLETED
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms	nan	COMPLETED
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).	nan	RECRUITING
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Comparison of Docosahexaenoic (DHA) Values in Patients With Polycystic Ovary Syndrome (PCOS)	nan	UNKNOWN
Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis	nan	COMPLETED
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer	nan	COMPLETED
Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease	nan	COMPLETED
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing	nan	UNKNOWN
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ALOX12 binder may also engage these)

Protein	Name	Similarity
P27479	—	1.000	P27479 →
ALOX15	Polyunsaturated fatty acid lipoxygenase ALOX15	1.000	landscape →
P55249	—	1.000	P55249 →
Q5RBE8	—	1.000	Q5RBE8 →
F1LQ70	—	1.000	F1LQ70 →
P12530	—	1.000	P12530 →
P39655	—	1.000	P39655 →
Q02759	—	0.994	Q02759 →
P16469	—	0.993	P16469 →
D3ZQF9	—	0.991	D3ZQF9 →
Q9BYJ1	—	0.988	Q9BYJ1 →
D3ZKX9	—	0.986	D3ZKX9 →
Q9WV07	—	0.983	Q9WV07 →
P39654	—	0.980	P39654 →
ALOX15B	Polyunsaturated fatty acid lipoxygenase ALOX15B	0.978	landscape →
P48999	—	0.973	P48999 →
P51399	—	0.971	P51399 →
P12527	—	0.971	P12527 →
A6NFQ2	—	0.971	A6NFQ2 →
O75342	—	0.971	O75342 →
B2RUP2	—	0.970	B2RUP2 →
O35936	—	0.970	O35936 →
ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.970	landscape →
Q8K4F2	—	0.968	Q8K4F2 →
O70582	—	0.967	O70582 →
Q5R8R3	—	0.965	Q5R8R3 →
Q643R3	—	0.964	Q643R3 →
Q9H6R4	—	0.964	Q9H6R4 →
Q149M9	—	0.963	Q149M9 →
Q5NVK5	—	0.962	Q5NVK5 →