Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 10/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | SI | P14410 | 2/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701680 | 0.89 | GAA (0.47) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL31569303 | 0.89 | GAA (0.47) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL17300893 | 0.88 | GAA (0.46) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL1128496 | 0.83 | MGAM (0.50) | GAATDP1PARP1MGAMSI | |
| SCHEMBL1129302 | 0.75 | PARP1 (0.37) | MEN1KMT2AL3MBTL1PARP1NPSR1 | |
| SCHEMBL5510483 | 0.75 | HRH4 (0.43) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL14958589 | 0.74 | GAA (0.51) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL6843925 | 0.74 | NPC1 (0.50) | GAAMEN1KMT2APOLBMAPT | |
| SCHEMBL1902643 | 0.74 | PARP1 (0.53) | GAAMEN1KMT2APARP1MGAM | |
| SCHEMBL29438962 | 0.74 | PARP1 (0.53) | GAAMEN1KMT2APARP1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |