SCHEMBL11293237

SCHEMBL11293237

C[Si](C)(Cl)Cc1cccc(C[Si](C)(C)Cl)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.34
BCHE P06276 1/20 0.34
PNMT P11086 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CHKA P35790 3/20 0.33
TAAR1 Q96RJ0 4/20 0.32
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
RAB9A P51151 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
CYP1A1 P04798 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP1B1 Q16678 1/20 0.32
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL122439 0.82 TP53 (0.43) TP53LOXL2
SCHEMBL9715903 0.80 TP53 (0.46) MEN1KMT2ATP53
SCHEMBL4447466 0.79 KMT2A (0.36) PNMTMEN1KMT2ATAAR1NPC1
SCHEMBL7188836 0.78 ESR1 (0.46)
SCHEMBL10945537 0.75 GRIN2D (0.35) MEN1KMT2ANPC1LMNARAB9A
SCHEMBL4850067 0.70 TSHR (0.38) MEN1KMT2ATAAR1NPC1RAB9A
SCHEMBL31366860 0.70 IDO1 (0.44) ACHEKMT2ATAAR1LMNACYP1A2
SCHEMBL8861689 0.70 PRKCI (0.46) NOS1NOS2
SCHEMBL11199377 0.70 TAAR1 (0.47) CHKATAAR1LMNACYP1A2
SCHEMBL5486477 0.70 TAAR1 (0.50) ACHETAAR1LMNACYP1A2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57146789-A None JP disclosed
JP-S57146789-A BISSILYLATED XYLENE TOSHIBA SILICONE CO LTD 1982-09-10 JP disclosed