Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296595 | 0.88 | HDAC6 (0.42) | HDAC8HDAC6HDAC1HDAC4HDAC7 | |
| SCHEMBL11301754 | 0.84 | PSEN1 (0.42) | HDAC8HDAC6HDAC1PSEN1PSEN2 | |
| SCHEMBL11303268 | 0.83 | ABL1 (0.37) | HDAC8HDAC6HDAC1PSEN1PSEN2 | |
| SCHEMBL11303328 | 0.83 | HDAC8 (0.37) | HDAC8HDAC6HDAC1PSEN1PSEN2 | |
| SCHEMBL11298752 | 0.82 | HDAC8 (0.42) | HDAC8HDAC6HDAC1PSEN1PSEN2 | |
| SCHEMBL11301603 | 0.80 | HDAC6 (0.38) | HDAC8HDAC6HDAC1HDAC4HDAC7 | |
| SCHEMBL11304464 | 0.79 | HDAC8 (0.37) | HDAC8HDAC6HDAC1PSEN1PSEN2 | |
| SCHEMBL11305647 | 0.79 | HDAC6 (0.41) | HDAC8HDAC6HDAC1HDAC11 | |
| SCHEMBL11299163 | 0.79 | HDAC6 (0.40) | HDAC8HDAC6HDAC1HDAC7PSEN1 | |
| SCHEMBL11304336 | 0.79 | HDAC6 (0.42) | HDAC8HDAC6HDAC1HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |