Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299347 | 0.86 | DYRK1A (0.54) | DYRK1ADYRK1BMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11301913 | 0.85 | DYRK1A (0.57) | DYRK1ADYRK1BMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10319618 | 0.84 | DYRK1A (0.67) | DYRK1ADYRK1B | |
| SCHEMBL11296377 | 0.83 | DYRK1A (0.61) | DYRK1ADYRK1BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11298554 | 0.82 | DYRK1A (0.79) | DYRK1ADYRK1B | |
| SCHEMBL10319359 | 0.81 | DYRK1A (0.58) | DYRK1ADYRK1B | |
| SCHEMBL10318579 | 0.81 | DYRK1A (0.69) | DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL11295058 | 0.80 | DYRK1A (0.48) | DYRK1ADYRK1BCNR2 | |
| SCHEMBL11303286 | 0.80 | DYRK1A (0.55) | DYRK1ADYRK1B | |
| SCHEMBL10321602 | 0.80 | DYRK1A (0.55) | DYRK1ADYRK1BKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |