Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 18/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299149 | 0.92 | DYRK1A (0.51) | DYRK1ADYRK1B | |
| SCHEMBL11298554 | 0.88 | DYRK1A (0.79) | DYRK1ADYRK1B | |
| SCHEMBL11295934 | 0.85 | DYRK1A (0.79) | DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL11297738 | 0.85 | DYRK1A (0.63) | DYRK1ADYRK1B | |
| SCHEMBL10322194 | 0.83 | DYRK1A (0.76) | DYRK1ADYRK1B | |
| Hydrochloric Acid SCHEMBL11300224 | 0.83 | DYRK1A (0.58) | DYRK1ADYRK1B | |
| SCHEMBL11295060 | 0.83 | DYRK1A (0.53) | DYRK1ADYRK1BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10322815 | 0.83 | DYRK1A (0.77) | DYRK1ADYRK1BSMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL11297240 | 0.81 | DYRK1A (0.58) | DYRK1ADYRK1BSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11295696 | 0.80 | DYRK1A (0.80) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098066-A1 | 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| WO-2012098066-A1 | 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |