Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 3/20 | 0.60 |
| ▸ | PDE4A | P27815 | 10/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | KMO | O15229 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308500 | 0.88 | TPH1 (0.78) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL309142 | 0.88 | TPH1 (0.78) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1129584 | 0.86 | TPH1 (0.59) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14967853 | 0.80 | TPH1 (0.54) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14967855 | 0.79 | TPH1 (0.62) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL309631 | 0.76 | TPH1 (0.51) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307423 | 0.76 | TPH1 (0.81) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307424 | 0.76 | TPH1 (0.81) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307765 | 0.74 | TPH1 (0.77) | TPH1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL307766 | 0.74 | TPH1 (0.77) | TPH1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282756-A1 | METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES | The Trustees of Columbia University in the City of New York (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009123978-A1 | METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-10-08 | — | — | WO | disclosed |