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Sugi Predict / Targets / TPH1

TPH1

Tryptophan 5-hydroxylase 1 · P17752 · TPH1 on Sugi Atlas →

19,524 patent compounds predicted against TPH1, 12,857 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL307395 SCHEMBL307395 1.00 20/20
SCHEMBL307611 SCHEMBL307611 1.00 20/20
SCHEMBL307612 SCHEMBL307612 1.00 20/20
SCHEMBL307738 SCHEMBL307738 1.00 20/20
SCHEMBL307739 SCHEMBL307739 1.00 20/20
SCHEMBL307901 SCHEMBL307901 1.00 20/20
SCHEMBL308166 SCHEMBL308166 1.00 20/20
SCHEMBL308167 SCHEMBL308167 1.00 20/20
SCHEMBL308207 SCHEMBL308207 1.00 20/20
SCHEMBL308216 SCHEMBL308216 1.00 20/20
SCHEMBL308221 SCHEMBL308221 1.00 20/20
SCHEMBL308509 SCHEMBL308509 1.00 20/20
SCHEMBL308510 SCHEMBL308510 1.00 20/20
SCHEMBL308718 SCHEMBL308718 1.00 20/20
SCHEMBL308719 SCHEMBL308719 1.00 20/20
SCHEMBL309002 SCHEMBL309002 1.00 20/20
SCHEMBL309188 SCHEMBL309188 1.00 20/20
SCHEMBL309189 SCHEMBL309189 1.00 20/20
SCHEMBL320652 SCHEMBL320652 1.00 20/20
SCHEMBL322334 SCHEMBL322334 1.00 20/20

Clinical trials — most relevant to TPH1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism PHASE4COMPLETED
Tryptophan MRI in People With Schizophrenia and Healthy Controls PHASE2/PHASE3COMPLETED
The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety PHASE2COMPLETED
Bioavailability Study of Psilocybin in Normal Adults PHASE1WITHDRAWN
Investigating Serotonin Signalling in IBD Patients nanRECRUITING
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke nanCOMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Serotonin, Serotonin Genetics(TPH2) and Emotion and Interference Processing nanUNKNOWN
Tryptophan Metabolism in Healthy Young Adults nanCOMPLETED
Psychobiological Characterization of Depression in Hepatitis C nanUNKNOWN
Serotonin Function During Depression nanCOMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder nanNOT_YET_RECRUITING
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients nanUNKNOWN
Effects of Saffron and Chamomile in Mild to Moderate Depression nanUNKNOWN
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders nanCOMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome nanUNKNOWN
Probiotic Supplementation in Severe Depression nanCOMPLETED
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram nanCOMPLETED
Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment nanCOMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI nanCOMPLETED
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder nanUNKNOWN
Interaction Between Genetic Factors and Maternal Stressors During Pregnancy in the Risk of Postpartum Depression nanCOMPLETED
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis nanCOMPLETED
Human Cerebral Blood Flow and Serotonin nanUNKNOWN
Analysis of Peripheral Serotonin Levels in a Control Cohort nanCOMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling nanUNKNOWN
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes nanNOT_YET_RECRUITING
Examination of Brain Serotonin Receptors in Patients With Mood Disorders nanCOMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder nanWITHDRAWN
Genetic and Biochemical Markers of Interferon-Induced Depression. nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TPH1 binder may also engage these)

ProteinNameSimilarity
P17290 — 1.000 P17290 →
P09810 — 1.000 P09810 →
P70080 — 1.000 P70080 →
P17276 — 1.000 P17276 →
Q2HZ26 — 1.000 Q2HZ26 →
P11982 — 1.000 P11982 →
PAH Phenylalanine-4-hydroxylase 1.000 landscape →
P16331 — 0.999 P16331 →
TPH2 Tryptophan 5-hydroxylase 2 0.999 landscape →
Q8CGU9 — 0.999 Q8CGU9 →
P17532 — 0.999 P17532 →
Q92142 — 0.999 Q92142 →
P04176 — 0.999 P04176 →
E5KBU3 — 0.999 E5KBU3 →
Q0EAB8 — 0.998 Q0EAB8 →
Q54XS1 — 0.998 Q54XS1 →
Q2KIH7 — 0.998 Q2KIH7 →
A0A060X6Z0 — 0.997 A0A060X6Z0 →
Q8CGV2 — 0.996 Q8CGV2 →
A8X3V8 — 0.996 A8X3V8 →
P90925 — 0.995 P90925 →
P90986 — 0.995 P90986 →
P24529 — 0.993 P24529 →
P04177 — 0.992 P04177 →
P00365 — 0.992 P00365 →
P17289 — 0.992 P17289 →
Q76IQ3 — 0.991 Q76IQ3 →
Q9USN5 — 0.991 Q9USN5 →
Q9STV0 — 0.991 Q9STV0 →
Q8L831 — 0.989 Q8L831 →