SCHEMBL1129646

SCHEMBL1129646

SCCn1cnc2ccccc21

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.78
LMNA P02545 7/20 0.64
SMN1; SMN2 Q16637 6/20 0.64
HTT P42858 4/20 0.64
EGLN3 Q9H6Z9 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
CYP11B1 P15538 5/20 0.58
CYP11B2 P19099 5/20 0.58
TNF P01375 1/20 0.58
TSHR P16473 2/20 0.57
NPSR1 Q6W5P4 1/20 0.57
ALOX15 P16050 1/20 0.57
RAB9A P51151 2/20 0.54
GAA P10253 1/20 0.54
MAPK1 P28482 1/20 0.53
PKM P14618 1/20 0.53
NPC1 O15118 1/20 0.53
MAPT P10636 1/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6442808 0.88 TDP1 (1.00) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL3020731 0.87 TDP1 (0.70) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL1645851 0.84 TDP1 (0.70) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL9814242 0.84 TDP1 (0.84) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL3161153 0.84 TDP1 (0.84) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL30294105 0.84 TDP1 (0.84) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL352046 0.82 TDP1 (0.81) TDP1LMNASMN1; SMN2HTTEGLN3
Ammonia Solution, Strong SCHEMBL7100443 0.82 TDP1 (0.81) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL353009 0.82 TDP1 (0.81) TDP1LMNASMN1; SMN2HTTEGLN3
SCHEMBL9814241 0.82 TDP1 (0.81) TDP1LMNASMN1; SMN2HTTEGLN3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9169873-A None JP disclosed
US-20190077894-A1 PROCESS FOR PREPARING CATALYSTS LANXESS DEUTSCHLAND GMBH (DE) 2019-03-14 US disclosed
EP-2952256-B1 METHOD FOR THE PRODUCTION OF CATALYSTS LANXESS DEUTSCHLAND GMBH (DE) 2017-05-17 EP disclosed
US-20150353660-A1 PROCESS FOR PREPARING CATALYSTS LANXESS DEUTSCHLAND GMBH (DE) 2015-12-10 US disclosed
EP-2952256-A1 METHOD FOR THE PRODUCTION OF CATALYSTS LANXESS Deutschland GmbH (DE) 2015-12-09 EP disclosed
US-8932976-B2 Preparation of catalyst for bisphenols production DOW GLOBAL TECHNOLOGIES LLC (US) 2015-01-13 US disclosed
EP-2158040-B1 PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION DOW GLOBAL TECHNOLOGIES INC (US) 2011-02-16 EP disclosed
US-20100152028-A1 PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION DOW GLOBAL TECHNOLOGIES LLC 2010-06-17 US disclosed
EP-2158040-A1 PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION Dow Global Technologies Inc. (US) 2010-03-03 EP disclosed
US-7524823-B2 Macrolides BASILEA PHARMACEUTICA AG (CH) 2009-04-28 US disclosed
WO-2008157025-A1 PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION DOW GLOBAL TECHNOLOGIES INC. (US) 2008-12-24 WO disclosed
US-20060264387-A1 Macrolides BASILEA PHARMACEUTICA AG (CH) 2006-11-23 US disclosed
EP-0933381-B1 HIGHLY SATURATED CARBOXYLATED NITRILE COPOLYMER RUBBER AND PROCESS FOR THE PRODUCTION THEREOF NIPPON ZEON CO (JP) 2003-05-21 EP disclosed
US-6534686-B1 Reacting aromatic hydroxy compound with carbonyl containing compound in presence of catalyst composition comprising polymeric resin component comprising protic acid functionality and sulfur-protected mercaptan promoter component GENERAL ELECTRIC COMPANY 2003-03-18 US disclosed
US-6410653-B1 ACRYLONITRILE-BUTADIENE COPOLYMER NIPPON ZEON CO., LTD. (JP) 2002-06-25 US disclosed
EP-0933381-A1 HIGHLY SATURATED CARBOXYLATED NITRILE COPOLYMER RUBBER AND PROCESS FOR THE PRODUCTION THEREOF NIPPON ZEON CO., LTD. (JP) 1999-08-04 EP disclosed
JP-H09169873-A RUBBER COMPOSITION FOR OPEN CROSS-LINKING AND CROSS-LINKING METHOD NIPPON OIL & FATS CO LTD 1997-06-30 JP disclosed
EP-0728752-A1 Triazole compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-28 EP disclosed
US-5405861-A Fungicides TAKEDA CHEMICAL INDUSTRIES, CO., LTD. (JP) 1995-04-11 US disclosed
EP-0421210-A2 Triazole compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1991-04-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264387-A1 Macrolides PPME1, MGAM, SMPD1 TDP1 687/4885LMNA 2723/4885SMN1; SMN2 3789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.