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Sugi Predict / Targets / PPME1

PPME1

Protein phosphatase methylesterase 1 · Q9Y570 · PPME1 on Sugi Atlas →

601 patent compounds predicted against PPME1, 253 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL16194668 SCHEMBL16194668 1.00 12/20
SCHEMBL16194669 SCHEMBL16194669 1.00 12/20
SCHEMBL16194670 SCHEMBL16194670 1.00 12/20
SCHEMBL3969689 SCHEMBL3969689 0.64 10/20
SCHEMBL3968075 SCHEMBL3968075 0.55 10/20
SCHEMBL24282442 SCHEMBL24282442 0.50 9/20
SCHEMBL1616366 SCHEMBL1616366 0.60 7/20
SCHEMBL3964674 SCHEMBL3964674 0.58 7/20
SCHEMBL5776529 SCHEMBL5776529 0.44 7/20
SCHEMBL2457308 SCHEMBL2457308 0.46 6/20
SCHEMBL2460281 SCHEMBL2460281 0.38 6/20
SCHEMBL29713729 SCHEMBL29713729 0.55 5/20
SCHEMBL11562973 SCHEMBL11562973 0.47 5/20
SCHEMBL4312459 SCHEMBL4312459 0.46 5/20
SCHEMBL4312461 SCHEMBL4312461 0.46 5/20
SCHEMBL10003780 SCHEMBL10003780 0.39 5/20
SCHEMBL29221130 SCHEMBL29221130 0.39 5/20
SCHEMBL6419604 SCHEMBL6419604 0.67 4/20
SCHEMBL11563220 SCHEMBL11563220 0.57 4/20
SCHEMBL28139909 SCHEMBL28139909 0.51 4/20

Clinical trials — most relevant to PPME1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Role of Mineralocorticoid Receptors in Vascular Function PHASE2/PHASE3COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients PHASE2COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer PHASE1/PHASE2RECRUITING
Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes PHASE2COMPLETED
Open-label Study on Treatment of Primary Aldosteronism With Everolimus PHASE2COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals PHASE1/PHASE2COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability PHASE1COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
Palliative Thoracic Radiotherapy Plus BKM120 PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
Study of Metabolic Modifications in Children With Noonan Syndrome nanCOMPLETED
Evaluation of Lysine-Specific Demethylase 1 nanWITHDRAWN
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma nanCOMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Target of Suv420h1/2 in Hepatocytes nanRECRUITING
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Quantification of GADD34 Expression in RA nanCOMPLETED
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Studies of the Tumour Suppressor Gene PTEN - Endometrial Cancer nanCOMPLETED
Study of Proteus Syndrome and Related Congenital Disorders nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a PPME1 binder may also engage these)

ProteinNameSimilarity
Q58DN4 — 1.000 Q58DN4 →
Q8BVQ5 — 1.000 Q8BVQ5 →
Q4FZT2 — 0.998 Q4FZT2 →
Q5R4F9 — 0.995 Q5R4F9 →
Q5XGS8 — 0.968 Q5XGS8 →
D2XV59 — 0.967 D2XV59 →
Q4R4Q3 — 0.964 Q4R4Q3 →
Q10568 — 0.964 Q10568 →
Q58DC5 — 0.964 Q58DC5 →
Q9P2I0 — 0.964 Q9P2I0 →
Q640Z1 — 0.963 Q640Z1 →
Q62433 — 0.962 Q62433 →
Q863I2 — 0.961 Q863I2 →
Q5SWU9 — 0.960 Q5SWU9 →
O08582 — 0.960 O08582 →
Q6DIX1 — 0.959 Q6DIX1 →
A4QNE0 — 0.959 A4QNE0 →
O88506 — 0.959 O88506 →
Q92597 — 0.959 Q92597 →
O55236 — 0.959 O55236 →
A0FKG7 — 0.959 A0FKG7 →
Q6JE36 — 0.958 Q6JE36 →
Q6H8D5 — 0.958 Q6H8D5 →
Q3SYX0 — 0.957 Q3SYX0 →
Q6DJD3 — 0.957 Q6DJD3 →
Q5FVD6 — 0.957 Q5FVD6 →
Q5R922 — 0.956 Q5R922 →
ACACA Acetyl-CoA carboxylase 1 0.956 landscape →
A0A8I5ZNK2 — 0.956 A0A8I5ZNK2 →
Q9C827 — 0.956 Q9C827 →