Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 9/20 | 0.65 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | ICMT | O60725 | 1/20 | 0.53 |
| ▸ | TACR2 | P21452 | 2/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11950552 | 1.00 | PIN1 (0.65) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL17991867 | 1.00 | PIN1 (0.65) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL11949522 | 1.00 | PIN1 (0.65) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL11952559 | 0.93 | PIN1 (0.61) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL11952560 | 0.93 | PIN1 (0.61) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL11294423 | 0.93 | PIN1 (0.61) | PIN1TAS1R3TAS1R1HDAC3HDAC4 | |
| SCHEMBL11296988 | 0.87 | TLR3 (0.62) | PIN1HDAC1 | |
| SCHEMBL11951259 | 0.87 | PIN1 (0.60) | PIN1HDAC1 | |
| SCHEMBL11951515 | 0.87 | TLR3 (0.62) | PIN1HDAC1 | |
| SCHEMBL17964392 | 0.87 | PIN1 (0.60) | PIN1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409880-B2 | Modulators of TLR3/dsRNA complex and uses thereof | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2665708-A2 | MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF | The Regents of the University of Colorado, A Body Corporate (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012099785-A2 | MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2012-07-26 | — | — | WO | disclosed |