Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11303497 | 0.89 | HDAC8 (0.46) | HDAC6HDAC1HDAC8HDAC2ALOX15 | |
| SCHEMBL11300774 | 0.89 | HDAC6 (0.41) | HDAC6HDAC1HDAC8HDAC3ALOX15 | |
| SCHEMBL11303321 | 0.87 | HDAC8 (0.44) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11297461 | 0.86 | HDAC8 (0.37) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11296626 | 0.85 | HDAC8 (0.49) | HDAC1HDAC8CA1KDM4EOPRM1 | |
| SCHEMBL11303510 | 0.84 | MEN1 (0.47) | MEN1KMT2AOPRM1OPRD1 | |
| SCHEMBL11299059 | 0.82 | HDAC6 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11299511 | 0.80 | HDAC8 (0.41) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11372589 | 0.80 | HDAC1 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL11301919 | 0.80 | HDAC1 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |