Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301919 | 0.89 | HDAC1 (0.48) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11372589 | 0.89 | HDAC1 (0.48) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11297190 | 0.82 | HDAC6 (0.44) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11299544 | 0.82 | HDAC1 (0.43) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11299528 | 0.81 | HDAC1 (0.40) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11299511 | 0.76 | HDAC8 (0.41) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11297461 | 0.74 | HDAC8 (0.37) | HDAC6HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL11300774 | 0.74 | HDAC6 (0.41) | HDAC6HDAC1HDAC8HDAC3HDAC11 | |
| SCHEMBL11303497 | 0.74 | HDAC8 (0.46) | HDAC6HDAC1HDAC8HDAC2 | |
| SCHEMBL11303321 | 0.73 | HDAC8 (0.44) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | claimed |
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |