Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.70 |
| ▸ | RELA | Q04206 | 2/20 | 0.70 |
| ▸ | SLC5A1 | P13866 | 8/20 | 0.68 |
| ▸ | SLC5A2 | P31639 | 7/20 | 0.68 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6398347 | 0.92 | NFKB1 (0.74) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL2282039 | 0.92 | NFKB1 (0.83) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL15457885 | 0.92 | NFKB1 (0.83) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL11302361 | 0.88 | NFKB1 (0.68) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL1937964 | 0.88 | NFKB1 (0.68) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL29435841 | 0.88 | NFKB1 (0.68) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL23440024 | 0.86 | CYP19A1 (0.67) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL2978651 | 0.86 | NFKB1 (0.66) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL30969937 | 0.86 | CYP19A1 (0.67) | NFKB1NFKB2RELASLC5A1SLC5A2 | |
| SCHEMBL29684688 | 0.86 | NFKB1 (0.66) | NFKB1NFKB2RELASLC5A1SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051819-A2 | Tetra-substituted benzene derivatives, their preparation and pharmaceutical preparations containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-05-19 | — | — | EP | claimed |