NFKB1

Nuclear factor NF-kappa-B p105 subunit · P19838 · NFKB1 on Sugi Atlas →

693,217 patent compounds predicted against NFKB1, 485,023 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Beclomethasone (SCHEMBL3183)	1.00	4/20
Dexamethasone (SCHEMBL3774)	1.00	4/20
Betamethasone (SCHEMBL4565)	1.00	4/20
Prochlorperazine (SCHEMBL18429)	1.00	4/20
Dexamethasone (SCHEMBL7548)	0.95	4/20
Betamethasone (SCHEMBL7594)	0.95	4/20
Beclomethasone (SCHEMBL7330)	0.92	4/20
Betamethasone (SCHEMBL7521)	0.92	4/20
Norepinephrine (SCHEMBL2609)	0.77	4/20
L-Norepinephrine (SCHEMBL2610)	0.77	4/20
SCHEMBL12261	0.55	4/20
Meprednisone (SCHEMBL9512)	0.55	4/20
SCHEMBL9394	0.42	4/20
Nifedipine (SCHEMBL3968)	1.00	3/20
Triamcinolone (SCHEMBL4447)	1.00	3/20
Curcumin (SCHEMBL8440)	1.00	3/20
Curcumin (SCHEMBL8441)	1.00	3/20
Fluphenazine (SCHEMBL19221)	1.00	3/20
Betamethasone (SCHEMBL7426)	0.93	3/20
Betamethasone (SCHEMBL7779)	0.90	3/20

Clinical trials — most relevant to NFKB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease	PHASE4	UNKNOWN
Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus	PHASE2/PHASE3	COMPLETED
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass	PHASE2/PHASE3	COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	PHASE2/PHASE3	COMPLETED
Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk	PHASE2/PHASE3	COMPLETED
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
Sodium Bicarbonate in Cardiac Surgery	PHASE2	COMPLETED
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients	PHASE1/PHASE2	COMPLETED
TNFSF11 Inhibition and Fertility: a Prospective Study	PHASE2	COMPLETED
Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot	PHASE2	COMPLETED
Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma	PHASE2	COMPLETED
PS-341 Alone and PS-341 Plus EPOCH Chemotherapy to Treat Non-Hodgkin's Lymphoma	PHASE2	COMPLETED
Bortezomib and Gemcitabine Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma	PHASE2	COMPLETED
Phase II Study of Curcumin vs Placebo for Chemotherapy-Treated Breast Cancer Patients Undergoing Radiotherapy	PHASE2	COMPLETED
Impact of Colchicine and Low-dose Naltrexone on COVID-19	PHASE2	COMPLETED
Ibrutinib, Obinutuzumab and Venetoclax for Patients With Chronic Lymphocytic Leukemia	PHASE2	COMPLETED
Diagnosis of Inflammatory Bowel Disease	nan	NOT_YET_RECRUITING
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient	nan	RECRUITING
MicroRNAs and Cytokines in Peri-Implantitis Tissue	nan	UNKNOWN
Novel Biomarkers in Inflammatory Bowel Disease	nan	COMPLETED
Mechanisms of Insulin Resistance in Humans	nan	COMPLETED
Magnesium and Vitamin D Combination for Post-COVID Syndrome	nan	COMPLETED
IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients	nan	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Cyclin-dependent Kinase Inhibitor 2A (Placental Senescence Marker) on Labor-related Signals	nan	UNKNOWN
Effects of Curcumin on Markers of Cardiovascular Risk in Patients With CAD	nan	WITHDRAWN
Vitamin D With Omega-3 or Metformin in Osteoarthritis	nan	NOT_YET_RECRUITING
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia	nan	NOT_YET_RECRUITING
The Pathophysiology of Bortezomib Induced Peripheral Neuropathy	nan	UNKNOWN
Effect of Atorvastatin on 5-Fluorouracil Induced Mucositis	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NFKB1 binder may also engage these)

Protein	Name	Similarity
P25799	—	1.000	P25799 →
Q04861	—	1.000	Q04861 →
O73630	—	1.000	O73630 →
Q6F3J0	—	1.000	Q6F3J0 →
Q63369	—	0.998	Q63369 →
Q9H1H9	—	0.998	Q9H1H9 →
NFKB2	Nuclear factor NF-kappa-B p100 subunit	0.996	landscape →
P98150	—	0.996	P98150 →
KAT8	Histone acetyltransferase KAT8	0.995	landscape →
P70600	—	0.995	P70600 →
KDM1A	Lysine-specific histone demethylase 1A	0.995	landscape →
KDM5D	Lysine-specific demethylase 5D	0.995	landscape →
O43150	—	0.994	O43150 →
INPP5B	Type II inositol 1,4,5-trisphosphate 5-phosphatase	0.994	landscape →
Q94527	—	0.994	Q94527 →
P28700	—	0.994	P28700 →
Q6IQX0	—	0.993	Q6IQX0 →
ASH2L	Set1/Ash2 histone methyltransferase complex subunit ASH2	0.993	landscape →
B2GUZ1	—	0.993	B2GUZ1 →
Q9DDT2	—	0.993	Q9DDT2 →
Q3UMY5	—	0.993	Q3UMY5 →
Q7Z3E5	—	0.993	Q7Z3E5 →
Q5XUN4	—	0.993	Q5XUN4 →
O14827	—	0.993	O14827 →
P41230	—	0.993	P41230 →
Q28161	—	0.993	Q28161 →
Q63618	—	0.993	Q63618 →
P10686	—	0.992	P10686 →
Q5BJS0	—	0.992	Q5BJS0 →
Q80Y84	—	0.992	Q80Y84 →