Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 10/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.36 |
| ▸ | CDK1 | P06493 | 7/20 | 0.36 |
| ▸ | CDK4 | P11802 | 7/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.36 |
| ▸ | CCND1 | P24385 | 7/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.36 |
| ▸ | CDK9 | P50750 | 7/20 | 0.36 |
| ▸ | CDK7 | P50613 | 6/20 | 0.36 |
| ▸ | CCNH | P51946 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13373313 | 0.86 | IKBKB (0.35) | IKBKBCDK2CCNT1CDK1CDK4 | |
| SCHEMBL11292385 | 0.85 | IKBKB (0.38) | IKBKBCDK2CCNT1CDK1CDK4 | |
| SCHEMBL11300059 | 0.84 | IKBKB (0.36) | IKBKBCDK2CCNT1CDK1CDK4 | |
| SCHEMBL13373281 | 0.79 | IKBKB (0.56) | IKBKBCDK2CDK9CDK7MEN1 | |
| SCHEMBL13373279 | 0.79 | CDK2 (0.42) | IKBKBCDK2CCNT1CDK1CDK4 | |
| SCHEMBL11299092 | 0.79 | ALDH1A1 (0.32) | MEN1ALDH1A1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL13592001 | 0.78 | CDK2 (0.46) | CDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13373284 | 0.78 | ADORA2A (0.32) | CDK2CCNE1MEN1ALDH1A1KMT2A | |
| SCHEMBL11298835 | 0.76 | CDK2 (0.37) | IKBKBCDK2CCNT1CDK1CDK4 | |
| SCHEMBL13373302 | 0.75 | CDK2 (0.34) | IKBKBCDK2CCNT1CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288400-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120183577-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120183577-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K1, MAP3K6 | IKBKB 540/4885CDK2 65/4885CCNT1 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.