Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 16/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1130271 | 0.97 | WNT3A (0.49) | WNT3AIGF1RPPARGPPARDPPARA | |
| SCHEMBL1131333 | 0.97 | WNT3A (0.48) | WNT3AIGF1RMEN1KMT2AATM | |
| Trifluoroacetic Acid SCHEMBL1130315 | 0.95 | IGF1R (0.46) | WNT3AIGF1RPPARGPPARDPPARA | |
| SCHEMBL1131295 | 0.94 | WNT3A (0.50) | WNT3AIGF1RMEN1KMT2AATM | |
| Trifluoroacetic Acid SCHEMBL1130144 | 0.94 | IGF1R (0.45) | WNT3AIGF1RPPARGPPARDPPARA | |
| Trifluoroacetic Acid SCHEMBL1130382 | 0.94 | IGF1R (0.44) | WNT3AIGF1RPPARGPPARDPPARA | |
| Trifluoroacetic Acid SCHEMBL1130075 | 0.94 | IGF1R (0.44) | WNT3AIGF1RPPARGPPARDPPARA | |
| SCHEMBL1129781 | 0.92 | IGF1R (0.48) | WNT3AIGF1RPPARGPPARDPPARA | |
| SCHEMBL1130244 | 0.92 | IGF1R (0.48) | WNT3AIGF1RPPARGPPARDPPARA | |
| SCHEMBL1131275 | 0.91 | IGF1R (0.47) | WNT3AIGF1RPPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773808-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-02-16 | — | — | EP | claimed |
| CN-101031559-A | Amino cyclic urea derivative, preparation method thereof and medical application of amino cyclic urea derivative as kinase inhibitor | AVENTIS PHARMA SA (FR) | 2007-09-05 | — | — | CN | claimed |
| EP-1773808-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-04-18 | — | — | EP | claimed |
| WO-2006010641-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-02-02 | — | — | WO | claimed |
| EP-1621536-A1 | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | Aventis Pharma S.A. (FR) | 2006-02-01 | — | — | EP | claimed |
| EP-1773808-B1 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2011-02-16 | — | — | EP | disclosed |
| US-7759379-B2 | Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | AVENTIS PHARMA S.A. (FR) | 2010-07-20 | — | — | US | disclosed |
| US-20080004300-A1 | Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors | AVENTIS PHARMA S.A. (FR) | 2008-01-03 | — | — | US | disclosed |
| CN-101031559-A | Amino cyclic urea derivative, preparation method thereof and medical application of amino cyclic urea derivative as kinase inhibitor | AVENTIS PHARMA SA (FR) | 2007-09-05 | — | — | CN | disclosed |
| EP-1773808-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010641-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2006-02-02 | — | — | WO | disclosed |
| EP-1621536-A1 | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors | Aventis Pharma S.A. (FR) | 2006-02-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004300-A1 | Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors | CDK2, CDK1, PRKAR2B | WNT3A 3260/4885IGF1R 446/4885PPARG 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.