⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397672 | 0.69 | — | — | |
| SCHEMBL1956799 | 0.67 | KDM4E (0.44) | — | |
| SCHEMBL8880726 | 0.67 | — | — | |
| SCHEMBL4856818 | 0.67 | KDM4E (0.44) | — | |
| SCHEMBL4856814 | 0.67 | KDM4E (0.44) | — | |
| SCHEMBL1358143 | 0.67 | — | — | |
| SCHEMBL1358140 | 0.67 | — | — | |
| SCHEMBL6194847 | 0.67 | — | — | |
| SCHEMBL11112133 | 0.67 | — | — | |
| SCHEMBL87987 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665712-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | The Board of Trustees of The Leland Stanford Junior University (US) | 2013-11-27 | — | — | EP | claimed |
| US-20130296349-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-11-07 | — | — | US | claimed |
| WO-2012099916-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-07-26 | — | — | WO | claimed |
| US-9145376-B2 | Quinazolinone inhibitors of dynein | THE ROCKEFELLER UNIVERSITY (US) | 2015-09-29 | — | — | US | disclosed |
| EP-2665712-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | The Board of Trustees of The Leland Stanford Junior University (US) | 2013-11-27 | — | — | EP | disclosed |
| US-20130296349-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-11-07 | — | — | US | disclosed |
| WO-2012099916-A1 | QUINAZOLINONE INHIBITORS OF DYNEIN | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-07-26 | — | — | WO | disclosed |